Group appliances according to use - Think of tasks you do in the kitchen, such as prep, cook, coffee, cleaning, serving, etc. You should put your dishwasher and sink next to each other, with a garbage can nearby for cleanup.
Keep storage areas spacious - If you use items multiple times a day or week, keep these in easily reachable locations. You may hide away your air popper for popcorn, but leave your Keurig out in plain sight.
Place landing areas next to major appliances - You will not want to be stuck trekking across the kitchen carrying a boiler full of scalding water. Consider a countertop landing area next to the stove to place this hot pot, and to help with safety.
Create a kids' zone - You may want a zone in the kitchen or directly off the kitchen to keep the kids at bay. You can supervise their activities, but still cook or entertain. Miller Construction's "the Rushmore" had this dropzone near the kitchen for the children's homework or office space.
Consider a zone for guests - If you entertain often, you should consider having an island with barstools, etc. This way they do not have to be off in another room by themselves while you are slaving away on the stove. This area would allow them to be in on the action with you, and you with them.